Time again for a new round of EMBARK Webinars. This fall we will have four fantastic main speakers, together with a group of excellent junior speakers. Sign up for the webinars today!
Sep 14, 14:00 UTC+2 Jon Hobman – Antimicrobial resistance in a UK dairy farm Kenyum Bagra – Invasion dynamics of AMR bacteria into microbiomes under stress [Register here]
Oct 5, 14:00 UTC+2 Stineke van Houte – Towards the development of CRISPR-Cas based tools to remove AMR from microbial communities Ruben Vazquez-Uribe – CRISPR-Cas antimicrobials: Resistance mechanisms [Register here]
Nov 9, 14:00 UTC+2 Iruka Okeke – Genomic surveillance of human-invasive Salmonella in Nigeria Miranda Wallace – Understanding and predicting resistance in Bacteroides fragilis group bacteria using clinical and modern genomics tools [Register here]
For those in the northern hemisphere… Summer is here ⛱️! With it, the EMBARK team brings a refreshing AMR digest with many sunshiny papers. Put your 🕶️ on and swim deep into many works that we have compiled for you: AMR in soil, water, clinical or livestock settings, antibiotic resistance gene ecology and evolution and more … for those in the southern hemisphere, we also wish you a happy reading despite the cold winter ^^
*Addressing a future pandemic: how can non-biological complex drugs prepare us for antimicrobial resistance threats? – Blackman, L. D., Sutherland, T. D., De Barro, P. J., Thissen, H., & Locock, K. E. – Materials Horizons Lewis D. Blackman et al. review the different ways in which bacteria develop resistance against antibiotics and alternative agents that could be employed. They focused on non-biological complex drugs (NBCDs) as the next generation antimicrobial agents. They outline the advancements in antimicrobial polymer materials, carbon nanomaterials, and inorganic nanomaterials and highlight the remaining challenges for their clinical translation.
*Environmental Dimensions of “One Health” to Combat Antimicrobial Resistance: Essential Research Needs – Jin, L., Pruden, A., Boehm, A. B., Alvarez, P. J., Raskin, L., Kohn, T., & Li, X. – Integrating Environmental Science & Technology In this viewpoint article, Jin et al. critically address the lack of relevance and impact on health outcomes in environmental AMR research. They invite to “better define impactful contributions from the environmental dimension of AMR as part of a broader “One Health” vision” by implementing and developing models in line with an anthropocentric context of bacterial transfer within the interface between environment and humans. The authors promote multidisciplinary cross-national participation and coordination to establish analytical approaches to interpret ARG in the environment comprehensively. Approaches to identify responsible agents or conditions that select for AMR evolution and fit-for-purpose treatment technologies for mitigating high-risk ARGs and ARB at crucial sources.
*A bottom-up view of antimicrobial resistance transmission in developing countries – Ikhimiukor, O.O., Odih, E.E., Donado-Godoy, P. and Iruka N. Okeke – Nature Microbiology This review from Odion O. Ikhimiukor et al. focuses on AMR transmission in low- and middle-income countries, emphasizing high-risk transmission points such as urban settings and food-animal handling. The authors describe the integration of top-down and bottom-up strategies as AMR-containment approaches. They suggest that technological innovations are required to control AMR in low- and middle-income settings.
*Globally distributed mining-impacted environments are underexplored hotspots of multidrug resistance genes – Yi, X., Liang, J. L., Su, J. Q., Jia, P., Lu, J. L., Zheng, J. & Zhu, Y. G. – The ISME Journal Yi et al. focused their work on giving further insight into antimicrobial resistance in mining-impacted environments. They suggest developing constant monitoring strategies as the mining sites represent an underexplored hotspot for multidrug resistance genes. Overall, they described around 54 high-quality ARG-carrying MAGs from the phylum Proteobacteria, Acidobacteria, Actinobacteria, Bacteroidota, Firmicutes, Nitrospira, Planctomycetes and Thermoplasmatota and confirmed high mobility of ARGs, mainly trough transposons and plasmid.
Very proud to share our publication "Metagenomic DNA sequencing for semi-quantitative pathogen detection from urine: a prospective, laboratory-based, proof-of-concept study", published in @LancetMicrobe today! https://t.co/cyLS5TSeRJ
🧵on the latest @DETECTIVE_AMR manuscript, which might be my favourite so far. It's about a quirky group of plasmids that accumulate and disseminate all sorts of accessory genes in Acinetobacter… 1/20 https://t.co/Yzid2Q5Y5z
Check out our newest work on phage-plasmids: https://t.co/7s2bRIE1xn Unlike other phages, they often encode #AMR genes and, of concern, also contribute to their spread (by infection and lysogenic conversion). !Thanks a lot! for great support and help @epcrocha & RemyBonnin!
Latest lab publication led by @amito@FinlayM – Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing https://t.co/93GQg9FpCl
1/14 A fun 🙂 thread on our latest paper, which touches on how bacteria such as Strep pneumo process antibiotics, how this can be exploited for new antimicrobial therapies and how tolerance is just a simple genetic change away. https://t.co/WjnQPN8ikW
Join CIDRAP-ASP on June 21, 6:00 – 7:15 pm CDT for a webinar discussing the importance of effective, data-driven infection prevention strategies (IPC) and antibiotic stewardship (AS) initiatives. It has been shown that IPC and AS reduce drug-resistant infections and diminish the burden of antimicrobial resistance (AMR) within healthcare systems. More information here.
AMR Studio Podcast Ep 39: Vanessa Carter & patient advocacy. A stewardship game. Evolution of antibiotic tolerance – Uppsala Antibiotic Center
May digest features review on the gut microbiota – urinary tract infections axis, novel antimicrobial compounds detected – the dynaplanins -, phage therapy tackling antibiotic-resistant bacteria and more.
We are excited to share with you EMBARK NEWS – after the SPRING #AMR WEBINARS we are already planning the fall #EMBARK2022: Join us and our invited speakers to discuss the latest AMR insights!
Join us for the last #EMBARK2022 before summer break ⛱️
Using competition, we found that Couchioplanes bacteria make a family of new antibiotics called dynaplanins! These small molecules act as metabolic inhibitors. Check out our latest publication by @DynaCockusRose to learn more:https://t.co/j6UmySL9QN
Ep. 39: the AMR STUDIO podcast – Carl-Fredrik Flach & sewage surveillance. Water chlorination & microbiome. C. difficile spread between humans & animals.
Extensive metagenomic analysis of the porcine gut resistome to identify indicators reflecting antimicrobial resistance – Yunyan Zhou – Microbiome *The diversity and distribution of antimicrobial resistance genes (ARGs) were studied using metagenomic sequencing data of gut microbiome samples from pigs. The AMR level was significantly higher in pigs at commercial farms. The ARGs diversity and 41 drug resistance classes were significantly different between cecum, lumen, and feces in pigs at commercial farms.
Antimicrobial resistance genes aph(3′)-III, erm(B), sul2 and tet(W) abundance in animal faeces, meat, production environments and human faeces in Europe – Dongsheng Yang – The Journal of Antimicrobial Chemotherapy *Antimicrobial resistance genes (ARGs) can be quantified using real-time quantitative PCR (qPCR), allowing comparisons across animal production chains. The authors have examined the abundance of ARGs in various animal species, production environments, and humans in Europe in this study. The sources of AMR variation have been identified. Data from qPCR and previously published metagenomic studies were compared to determine the strength of the correlation between the ARGs abundances.
Multiwalled Carbon Nanotubes Promote Bacterial Conjugative Plasmid Transfer – Katrin Weise, Lena Winter, Emily Fischer, David Kneis, Magali de la Cruz Barron, Steffen Kunze, Thomas U. Berendonk, Dirk Jungmann, Uli Klümper – Microbiology Spectrum *In this paper, the authors have highlighted the importance of multi-walled carbon nanotubes (MWCNTs) used in various products related to bacterial plasmid transfer in aquatic environments. MWCNTs form bigger agglomerates and provide novel surfaces for bacterial interactions, promoting the spread of antimicrobial resistance genes in microbial communities.
Gather 'round, Twitterverse! I have a story to tell about a project that's been very satisfying to work on!
It revolves around a question that has nagged at me for years: why do some antibiotic-resistance mutations seem to not cause any fitness tradeoffs? https://t.co/Oyvzxkbly3
The AMR Studio podcast, Ep 37: Celia Souque & evolution + outreach. Colistin and silver. Qualitative research on AMS.
You are all welcome to join the third presentation at the EDAR6 Count down webinar series at April 20th at 14:00 (CEST), where Professor Kornelia Smalla will present recent work.
The AMR March digest features the latest publications on global health risk of antibiotic resistance genes, bacterial responses to antibiotic combinations, Hi-C assisted metagenomics for AMR resistance tracking and more. Happy #AMR reading!
Assessment of global health risk of antibiotic resistance genes – Zhenyan Zhang – Nature Communications *Authors developed a novel method for quantitatively surveilling the health risk of ARGs, by integrating human accessibility, mobility, pathogenicity and clinical availability. Antibiotic resistance risk was detected all around the world, even in the polar region. Human-associated habitats posed the highest risk of antibiotic resistance than other habitats.
ARGs shared between the human-associated and three main habitats. Number in the circles represents the number of shared ARGs.
After long silence, finally a tweet from me! A new paper from my group (and me!) is out in @NatureComms! We used some ~6000 #bacteria sequences to study role of plasmids and transposons on world-wide spreading of NDM #AntibioticResistance gene.
Very pleased this has seen the light of day @eLife big effort to get it completed by @OUCRU_Vietnam@GSK has several key findings/observations for developing new antimicrobials again #AMR organisms https://t.co/YnqcMNVaWL
The moment has finally come… My first (Co) first author paper is out today in @ISMEJournal 🥳 and highlighted by @Cambridge_Uni news 😱🤩 We studied how polymicrobial interactions affect drug effectiveness and a new colistin resistance mechanism 🤯 👇https://t.co/BQPi2DHIJk
The first paper of my postdoc is out! 😁 In our review, my colleagues and I explored the gut resistome, and how commensal organisms, including Live Microbial Therapeutics, contribute to the transfer of antibiotic-resistance genes in the gut: a 🧵 (1/6)https://t.co/5M06fWF3qQpic.twitter.com/Q7GzSuZAcM
IntegronFinder was discreetly published a few years ago with an analysis of the distribution of integrons and description of the novel elements CALIN. Here’s version 2, with improved software, some new options and more adapted output.https://t.co/dICB2U3VIk